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Safeguarding Ribosomes During Cellular Stress

Cells face difficulties in maintaining ribosome integrity under stress conditions, such as glucose starvation. The E3 ligase HOIL-1 plays a crucial role in protecting ribosomes, and its mutation can lead to sensitivity to disulfidptosis. This sensitivity can be triggered by ZAKα–ATF4 and affects the cytoprotective roles of PABPC1 and MKRN1.

Science, Biology, Cell Biology