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Maladaptive circuit reactivation in mental health conditions

Chronic stress and inflammation may lead to reduced neuronal excitability margins, causing involuntary reactivation of maladaptive circuits in depression, PTSD, and psychosis-related phenotypes. This can result in intrusive experiences such as rumination, flashbacks, and voice-hearing. The challenge lies in understanding and addressing the underlying mechanisms driving these conditions.

Science, Biology, Neuroscience