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Nonlinear Filtration Performance Scaling in Bioprocessing

Filtration performance in downstream bioprocessing often fails to scale linearly, resulting in faster-than-expected fouling, nonlinear pressure increases, and reduced effective filter capacity. This issue arises even when feed composition is consistent, and is not well captured in small-scale testing. The challenge is to identify the primary factors driving this nonlinearity.

Engineering, Core Engineering, Electrical Engineering