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Create Multi-Dimensional Protein Design

Develop methods to design proteins that can exist in multiple stable conformations and switch between them in response to different signals, essentially creating shape-shifting proteins. This involves understanding protein folding landscapes, designing bistable or multistable proteins, and controlling conformational switches. Applications include molecular machines, smart therapeutics, and adaptive biomaterials. Current protein design typically focuses on single stable structures. Multi-conformational proteins could enable more sophisticated biological functions and dynamic responses to changing conditions.

Science, Chemistry, Biochemistry