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Resolve Organ Transplant Rejection

Organ transplants save lives but require lifelong immunosuppression, causing infections, cancer risk, and eventual organ failure, while organ shortages mean 17 Americans die daily waiting for transplants. This challenge involves preventing transplant rejection without suppressing overall immune function or developing methods to create personalized organs. Barriers include immune compatibility, chronic rejection mechanisms, immunosuppression side effects, and organ shortage. Without solving transplant rejection, organ transplant recipients will face shortened lifespans, increased disease risk, and eventual organ failure, while organ shortages will worsen. Success could eliminate immunosuppression needs, extend transplant survival indefinitely, reduce transplant complications, and potentially eliminate organ shortages while saving thousands of lives annually.

Science, Biology, Immunology