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Understand Chronic Inflammation Mechanisms

Chronic inflammation underlies most age-related diseases including heart disease, diabetes, and dementia, yet we cannot predict who will develop chronic inflammation or prevent it effectively. This challenge involves understanding what triggers and maintains chronic inflammatory responses and how to resolve them. Barriers include inflammation complexity, resolution mechanisms, tissue-specific responses, and individual variation in inflammatory responses. Without understanding chronic inflammation, age-related diseases will continue increasing, healthspan will remain limited, and inflammatory diseases will cause enormous suffering. Success could prevent most age-related diseases, extend healthy lifespan, resolve chronic inflammatory conditions, and improve quality of life dramatically while reducing healthcare costs for aging populations.

Science, Biology, Immunology