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Develop Precision Microbial Editing

We need to modify microbial communities precisely without disrupting beneficial functions, yet current approaches lack precision and predictability. This challenge involves developing tools for precise microbial community engineering. Barriers include editing precision, off-target effects, community stability, and ecological consequences. Without precision microbial editing, microbiome therapies will remain crude, beneficial functions will be disrupted, and microbial engineering will be unpredictable. Success could provide precise microbiome modification, maintain beneficial functions, enable targeted microbial therapies, and create predictable microbial engineering while advancing microbiome medicine.

Science, Biology, Microbiology