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Incomplete Transcript Annotation in Cynomolgus Macaque Genome

The current annotation of the T2T-MFA8v1.1 cynomolgus macaque reference genome lacks a well-defined canonical transcript framework, limiting its usability for downstream applications. This gap causes ambiguity in exon-level targeting, increases the risk of off-target effects, and leads to inconsistent interpretation of expression and isoform usage.

Science, Biology, Genetics