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Missing Full-Length 3D Structure for TP53 Protein

The lack of a complete, atom-by-atom model for the full-length TP53 protein sequence hinders understanding of its structure and function. The existing fragments, such as DNA-binding and tetramerization domains, do not provide a comprehensive view. The challenge lies in determining whether the absence of a full-length structure is due to intrinsically disordered regions or specific isoform/folding issues.

Science, Biology, Molecular Biology