It is not amyloid plaques that cause sleep loss in Alzheimer’s disease but microglia. The appearance of plaques cost Alzheimer’s mice 1.5-2 hours of sleep per night. Microglia-blocking drugs gave the Alzheimer’s mice an extra two hours of sleep per night, extending restorative sleep periods.

It is not amyloid plaques that cause sleep loss in Alzheimer’s disease but microglia. The appearance of plaques cost Alzheimer’s mice 1.5-2 hours of sleep per night. Microglia-blocking drugs gave the Alzheimer’s mice an extra two hours of sleep per night, extending restorative sleep periods.